1-Epi-fortimicin A and derivatives

1-Epi-fortimicin A and derivatives

A 1-Epi fortimicin represented by the formula wherein: R1 is hydrogen or loweralkyl; R2 is hydrogen or hydroxyl, R3 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, amin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CARNEY, RONALD E, MCALPINE, JAMES B
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:A 1-Epi fortimicin represented by the formula wherein: R1 is hydrogen or loweralkyl; R2 is hydrogen or hydroxyl, R3 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, acyl, aminoacyl, diaminoacyl, hydroxyacyl, hydroxy-substituted aminoacyl, hydroxy-substituted diaminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted N-loweralkylaminoacyl or hydroxy-substituted N,N-diloweralkylaminoacyl; R4 is hydrogen or methyl; and the pharmaceutically acceptable salts thereof.