Intermediates for preparing anti-inflammatory phenyl-lower-alkylamines
N-{3- and 4-[R1-(phenyl)-C(=X)]-phenyl-lower-alkyl}amines, useful as anti-inflammatory agents, are prepared either by reduction of 3- or 4-[R1-(phenyl)-CO]-phenyl-lower-alkanoylamines, which are also useful as anti-inflammatory agents; by benzoylating a phenyl-lower-alkylamine; by reaction of a 3- o...
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Sprache: | eng |
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Zusammenfassung: | N-{3- and 4-[R1-(phenyl)-C(=X)]-phenyl-lower-alkyl}amines, useful as anti-inflammatory agents, are prepared either by reduction of 3- or 4-[R1-(phenyl)-CO]-phenyl-lower-alkanoylamines, which are also useful as anti-inflammatory agents; by benzoylating a phenyl-lower-alkylamine; by reaction of a 3- or 4-lithiophenyl-lower-alkylamine with a R1-(phenyl)-carboxaldehyde, a R1-(phenyl)-lower-alkyl ketone or a R1-(phenyl)-carbonitrile or by transformations involving manipulations of a carbonyl or carbinol group. |
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