Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds

The present invention provides Diaryl-(1-azabicyclo [2.2.2]octan-2-yl)alkanols of the formula and the pharmaceutically acceptable acid addition salts thereof wherein R is a cycloalkanol having 4-8 carbon atoms, an alkanol having 1-2 carbon atoms, or a radical of the formula wherein R1 and R2 are eac...

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Bibliographische Detailangaben
Hauptverfasser:	YEN, CHUNG H, DEASON, JAMES R
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides Diaryl-(1-azabicyclo [2.2.2]octan-2-yl)alkanols of the formula and the pharmaceutically acceptable acid addition salts thereof wherein R is a cycloalkanol having 4-8 carbon atoms, an alkanol having 1-2 carbon atoms, or a radical of the formula wherein R1 and R2 are each H or a C1-C5 alkyl, and R3 is H or an acyl of the formula wherein R4 is H or a C1-C4 alkyl. These alkanols are useful as antidiarrheal agents.