New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same

A compound effective in the treatment of diabetic angiopathy, i.e. a selective beta -receptor blocker has the formula (I) wherein: R2 is a hydrogen or alkyl having one to five carbon atoms, R3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KISS, ILONA, LITERATI, PETER N, SIMAY, ANTAL, VIRAG, SANDOR, FARAGO, KATALIN, SZENTIVANYI, MATYAS, TAKACS, KALMAN
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator KISS, ILONA
LITERATI, PETER N
SIMAY, ANTAL
VIRAG, SANDOR
FARAGO, KATALIN
SZENTIVANYI, MATYAS
TAKACS, KALMAN
description A compound effective in the treatment of diabetic angiopathy, i.e. a selective beta -receptor blocker has the formula (I) wherein: R2 is a hydrogen or alkyl having one to five carbon atoms, R3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R2 and R3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl, R5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms, R6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US4187220A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US4187220A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US4187220A3</originalsourceid><addsrcrecordid>eNqFjLEKwjAURbs4iPoNvlHBgLaCriKKkw7qLI_k1QaavJDE2n6DP20K7k6Xc8_lDrPPmd5wEbNCoNGWRS6qTnluO-E8u66e973iVhsCRV43GHVDYQFJSwoBSvYQK0pMDn2ybHv2xCWgVeAq9AYlvaKWWINk4zjofhYS2IjaavuEgIbG2aDEOtDkl6Nsejzc9idBjh8UXHqxFB_363q13eT5clf8X3wBaQBM7w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same</title><source>esp@cenet</source><creator>KISS, ILONA ; LITERATI, PETER N ; SIMAY, ANTAL ; VIRAG, SANDOR ; FARAGO, KATALIN ; SZENTIVANYI, MATYAS ; TAKACS, KALMAN</creator><creatorcontrib>KISS, ILONA ; LITERATI, PETER N ; SIMAY, ANTAL ; VIRAG, SANDOR ; FARAGO, KATALIN ; SZENTIVANYI, MATYAS ; TAKACS, KALMAN</creatorcontrib><description>A compound effective in the treatment of diabetic angiopathy, i.e. a selective beta -receptor blocker has the formula (I) wherein: R2 is a hydrogen or alkyl having one to five carbon atoms, R3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R2 and R3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl, R5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms, R6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1980</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19800205&amp;DB=EPODOC&amp;CC=US&amp;NR=4187220A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19800205&amp;DB=EPODOC&amp;CC=US&amp;NR=4187220A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KISS, ILONA</creatorcontrib><creatorcontrib>LITERATI, PETER N</creatorcontrib><creatorcontrib>SIMAY, ANTAL</creatorcontrib><creatorcontrib>VIRAG, SANDOR</creatorcontrib><creatorcontrib>FARAGO, KATALIN</creatorcontrib><creatorcontrib>SZENTIVANYI, MATYAS</creatorcontrib><creatorcontrib>TAKACS, KALMAN</creatorcontrib><title>New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same</title><description>A compound effective in the treatment of diabetic angiopathy, i.e. a selective beta -receptor blocker has the formula (I) wherein: R2 is a hydrogen or alkyl having one to five carbon atoms, R3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R2 and R3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl, R5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms, R6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1980</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjLEKwjAURbs4iPoNvlHBgLaCriKKkw7qLI_k1QaavJDE2n6DP20K7k6Xc8_lDrPPmd5wEbNCoNGWRS6qTnluO-E8u66e973iVhsCRV43GHVDYQFJSwoBSvYQK0pMDn2ybHv2xCWgVeAq9AYlvaKWWINk4zjofhYS2IjaavuEgIbG2aDEOtDkl6Nsejzc9idBjh8UXHqxFB_363q13eT5clf8X3wBaQBM7w</recordid><startdate>19800205</startdate><enddate>19800205</enddate><creator>KISS, ILONA</creator><creator>LITERATI, PETER N</creator><creator>SIMAY, ANTAL</creator><creator>VIRAG, SANDOR</creator><creator>FARAGO, KATALIN</creator><creator>SZENTIVANYI, MATYAS</creator><creator>TAKACS, KALMAN</creator><scope>EVB</scope></search><sort><creationdate>19800205</creationdate><title>New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same</title><author>KISS, ILONA ; LITERATI, PETER N ; SIMAY, ANTAL ; VIRAG, SANDOR ; FARAGO, KATALIN ; SZENTIVANYI, MATYAS ; TAKACS, KALMAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US4187220A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1980</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>KISS, ILONA</creatorcontrib><creatorcontrib>LITERATI, PETER N</creatorcontrib><creatorcontrib>SIMAY, ANTAL</creatorcontrib><creatorcontrib>VIRAG, SANDOR</creatorcontrib><creatorcontrib>FARAGO, KATALIN</creatorcontrib><creatorcontrib>SZENTIVANYI, MATYAS</creatorcontrib><creatorcontrib>TAKACS, KALMAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KISS, ILONA</au><au>LITERATI, PETER N</au><au>SIMAY, ANTAL</au><au>VIRAG, SANDOR</au><au>FARAGO, KATALIN</au><au>SZENTIVANYI, MATYAS</au><au>TAKACS, KALMAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same</title><date>1980-02-05</date><risdate>1980</risdate><abstract>A compound effective in the treatment of diabetic angiopathy, i.e. a selective beta -receptor blocker has the formula (I) wherein: R2 is a hydrogen or alkyl having one to five carbon atoms, R3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R2 and R3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl, R5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms, R6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US4187220A
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T04%3A29%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KISS,%20ILONA&rft.date=1980-02-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS4187220A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true