Process for preparing steroidal 3-oxo-4,6-dienes such as 17-hydroxy-3-oxo-17{60 -pregna-4,6-diene-21-carboxylic acid{65 -lactone
A process for preparing 17-hydroxy-3-oxo-17 alpha -pregna-4,6-diene-21-carboxylic acid gamma -lactone by contacting 17-hydroxy-3-oxy-17 alpha -pregna-3,5-diene-21-carboxylic acid gamma -lactone with an appropriate halogenating agent in the presence of an amine base, the corresponding hydrohalide sal...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | A process for preparing 17-hydroxy-3-oxo-17 alpha -pregna-4,6-diene-21-carboxylic acid gamma -lactone by contacting 17-hydroxy-3-oxy-17 alpha -pregna-3,5-diene-21-carboxylic acid gamma -lactone with an appropriate halogenating agent in the presence of an amine base, the corresponding hydrohalide salt thereof, and approximately 1-2 molar equivalents (relative to the lactonic starting material) of water, using a cold solvent as the contact medium, and heating the resultant mixture with a dehydrohalogenating agent, is disclosed. |
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