Hydrosoluble rifamycins and process for their preparation
This application relates to hydrosoluble rifamycins consisting of a molecular associations between a rifamycin derivative and an alkaline salt of an organic acid in a molar ratio 1 rifamycin to 0.5 to 5 alkali metal salt. These hydrosoluble rifamycins are obtained by solubilization of the respective...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | This application relates to hydrosoluble rifamycins consisting of a molecular associations between a rifamycin derivative and an alkaline salt of an organic acid in a molar ratio 1 rifamycin to 0.5 to 5 alkali metal salt. These hydrosoluble rifamycins are obtained by solubilization of the respective rifamycin derivatives with the selected solubilizing agent, in a suitable organic solvent and they are isolated through dilution with a hydrocarbon, after a vacuum concentration by filtration and drying, or through evaporation. These products realize a prolonged gutliver recycling and a lower toxicity, against the liver cell. |
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