Biphenylyl ethers and method of use

Biphenylyl ethers and method of use

Biphenylyl ethers of the formula R-O-CH2-CR1(OH)-CH2Z wherein R1 is H or CH3; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NOWAK, HERBERT, JONAS, ROCHUS, SCHACHT, ERICH, MEHRHOF, WERNER, SIMANE, ZDENEK
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Biphenylyl ethers of the formula R-O-CH2-CR1(OH)-CH2Z wherein R1 is H or CH3; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I, CF3, NO2 and piperidino or, when R1 is CH3 or when Z is homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino, unsubstituted biphenyl, and the physiologically acceptable acid addition salts thereof, possess cholesterol blood-level-lowering activity and can be produced by reacting a compound of the formula R-O-CH2-Y wherein Y is or -CR1(OH)-CH2X, X being Cl, Br, I or a free or functionally modified OH-group, with an amine of the formula H-Z.