Method of preparing N{HD 1{B -(2{40 -furanidyl)-5-substituted uracils

Method of preparing N{HD 1{B -(2{40 -furanidyl)-5-substituted uracils

A method of preparing N1-(2'-furanidyl)-substituted uracils having the general formula where R is selected from the group consisting of hydrogen, halogen, and alkyl, consists in that 2,3-dihydrofuran is processed with anhydrous hydrogen chloride in a medium of an organic chlorinated aliphatic h...

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Bibliographische Detailangaben
Hauptverfasser: VEINBERG, ARTUR KARLOVICH, SIDOROV, ALEXANDR BORISOVICH, LAZDINSH, ARVID AVGUSTOVICH, GILLER, SOLOMON ARONOVICH
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A method of preparing N1-(2'-furanidyl)-substituted uracils having the general formula where R is selected from the group consisting of hydrogen, halogen, and alkyl, consists in that 2,3-dihydrofuran is processed with anhydrous hydrogen chloride in a medium of an organic chlorinated aliphatic hydrocarbon solvent, and the thus formed product is reacted with 2,4-bis-(trimethylsilyloxy)-5R-substituted pyrimidines at a temperature not above 10 DEG C with subsequent isolation of the end product.