New aminophenylamidines, their production and their medicinal use

4-Amino substituted phenylamidine are anthelmintics. The compounds, of which N-(4-aminophenyl)N',N'-dimethylacetamidine is a representative embodiment, can be prepared through treatment of a 4-amino aniline with a carboxylic acidamide or thioamide, reduction of an appropriately substituted...

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Hauptverfasser: FLUCKE, WINFRIED, WOLLWEBER, HARTMUND
Format: Patent
Sprache:eng
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Zusammenfassung:4-Amino substituted phenylamidine are anthelmintics. The compounds, of which N-(4-aminophenyl)N',N'-dimethylacetamidine is a representative embodiment, can be prepared through treatment of a 4-amino aniline with a carboxylic acidamide or thioamide, reduction of an appropriately substituted 4-amino-phenylamidine, optionally followed by alkylation of the resultant 4-aminophenylamidine, formation of a Schiff base followed by quaternization and hydrolysis, or hydrolysis of a 4-acylaminophenylamidine.