NON-THROMBOGENIC PLASTICS

Non-thrombogenic plastic materials are prepared by a process which first fluorinates polyolefins or polyesters under conditions which produce both fluoride groups and reactive carboxyl groups and then reacts the carboxyl group on the substrate with plasminokinase enzymes which activate plasminogene...

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Bibliographische Detailangaben
Hauptverfasser:	MANLY, DONALD G
Format:	Patent
Sprache:	eng
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DISINFECTION, STERILISATION, OR DEODORISATION OF AIR GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP
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Beschreibung
Zusammenfassung:	Non-thrombogenic plastic materials are prepared by a process which first fluorinates polyolefins or polyesters under conditions which produce both fluoride groups and reactive carboxyl groups and then reacts the carboxyl group on the substrate with plasminokinase enzymes which activate plasminogene to plasmin. Such treated plastic materials can be used in devices, coming in direct contact with blood without accelerating clotting, as in membranes for blood dialysis and in other extracorporeal biomedical devices as well as in devices and conduits intended for prosthesis or body implants.