CORONARY DILATOR IN A PHARMACEUTICAL DOSAGE UNIT FORM

Procedure for the production of coronary agents in gelatin capsules breakable by bite, containing 4- (2 "-nitrophenyl) -2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine and a polyalkylene glycol, of administration per you; characterized in that in a first step, a coronary agent with rapid perlingually resorbable action is prepared, mixing, under yellow sodium light, in arbitrary sequence, (a) 1 part by weight of 4- (2''nitro-phenyl) -2, 6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine, (b) 6 to 50, preferably 15 to 35, parts by weight of polyalkylene glycol with 2-3 carbon atoms in the alkylene radicals and with an average molecular weight from 200 to 600, 1 to 10 parts by weight of lower alcohols with 1 to 3 hydroxyl groups, especially glycerin; (d) 1 to 10 parts by weight of water, and, optionally, subsequent customary auxiliary agents, and in a second step, the solution thus obtained is filled into gelatin capsules containing a dye that absorbs light with wavelength from 280 to 420 nm, especially the food dye gelborange-s (color index 15 985) and opacifying agents, especially titanium dioxide, forming these two-gelatin gelatin capsules by the "rotary-die" procedure ", first in two half bowls that are then welded except for a small opening for the filling of the active substance solution and which, after filling with the solution, are completely sealed by welding. (Machine-translation by Google Translate, not legally binding)