PIPERIDYLIDENE SUBSTITUTED CYCLOHEPTA(1 2-B)THIOPHENES

1289956 Benzocycloheptathiophenes SANDOZ Ltd 26 Jan 1970 [7 Feb 1969] 3608/70 Heading C2C Novel compounds of the formula where X is (a) NOH or (b) are prepared by (b) oxidizing a compound I where X is N-CH 3 with hydrogen peroxide in an inert solvent or (a) reacting a compound I where X is NH with an acyl peroxide in an inert solvent and hydrolysing the resulting acyl hydroxylamine to give I(a). A pharmaceutical composition of compounds I(a) or (b) or pharmaceutically acceptable salts thereof, alone or with a solid or liquid diluent, show histaminolytic, serotonin-antagonistic and acetylcholin-antagonistic effects.