21-SUBSTITUTED 6-CHLORO - 16ALPHA,17ALPHA-ISOPROPYL-IDENEDIOXY-PREGNA - 4,6 - DIENE-3,20-DIONE AND METHOD OF PREPARING THE SAME

21-SUBSTITUTED 6-CHLORO - 16ALPHA,17ALPHA-ISOPROPYL-IDENEDIOXY-PREGNA - 4,6 - DIENE-3,20-DIONE AND METHOD OF PREPARING THE SAME

1,270,373. 6-Chloropregnadienes. AMERICAN CYANAMID CO. 6 Feb., 1970 [20 March, 1969], No. 5901/70. Heading C2U. The invention comprises 6-chloro-21-hydroxy - 16α,17α - isopropylidenedioxy - 4,6- pregnadiene - 3,20 - dione 21 - methanesulphonate (VIIC) and 6,21 - dichloro - 16α,17α- isopropylidenedio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MILTON DAVID HELLER, ROBERT HERMAN LENHARD, SEYMOUR BERNSTEIN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Zusammenfassung:1,270,373. 6-Chloropregnadienes. AMERICAN CYANAMID CO. 6 Feb., 1970 [20 March, 1969], No. 5901/70. Heading C2U. The invention comprises 6-chloro-21-hydroxy - 16α,17α - isopropylidenedioxy - 4,6- pregnadiene - 3,20 - dione 21 - methanesulphonate (VIIC) and 6,21 - dichloro - 16α,17α- isopropylidenedioxy - 4,6 - pregnadiene - 3,20- dione (VIID), and their preparation from 3#,21- dihydroxy - 16α,17α - isopropylidenedioxy - 5- pregnen - 20 - one diacetate (I) by the sequence: I # 5,6# - epoxy - 3#,21 - dihydroxy - 16α,17α - isopropylidenedioxy - 5#- pregnan - 20 - one diacetate # 3#,5,6#,21- tetrahydroxy - 16α,17α - isopropylidenedioxy - 5α- pregnan - 20 - one 3,21 - diacetate # 3#,5,21. trihydroxy - 16α,17α - isopropylidenedioxy - 5α- pregnane - 6,20 - dione 3,21 - diacetate # 3#, 21 - dihydroxy - 16α,17α - isopropylidenedioxy - 4- pregnene - 6,20 - dione diacetate # 6 - chloro- 3#,21 - dihydroxy - 16α,17α - isopropylidenedioxy - 4,6 - pregnadien - 20 - one diacetate # 6 - chloro - 3#,21 - dihydroxy - 16α,17α - isopropylidenedioxy 4,6 - pregnadien - 20 - one # 6 - chloro - 21 - hydroxy - 16α,17α - isopropylidenedioxy-4,6-pregnadiene-3,20-dione (characterized as the acetate thereof) # VIIC # VIID. Compounds VIIC and VIID are stated to be antifertility agents, and may be made up with carriers into pharmaceutical compositions. Routes of administration are not stated.