1 - (SUBSTITUTED) - 5 - AMINOTETRAZOLES AND TREATMENT OF INFLAMMATION OF THE ANIMAL ORGANISM THEREWITH
1,209,880. 1 - Substituted 5 - aminotetrazoles. ARMOUR PHARMACEUTICAL CO. 9 Oct., 1967 [10 Oct., 1966], No. 29250/70. Divided out of 1,208,116. Heading C2C. Novel 1 - substituted - 5 - aminotetrazoles of the general formula wherein R is a monobromo-, monofluoro-, dichloro- or monomethyl-phenyl or mo...
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| creator | TAKASHI ENKOJI CHARLES D. BOSSINGER |
| description | 1,209,880. 1 - Substituted 5 - aminotetrazoles. ARMOUR PHARMACEUTICAL CO. 9 Oct., 1967 [10 Oct., 1966], No. 29250/70. Divided out of 1,208,116. Heading C2C. Novel 1 - substituted - 5 - aminotetrazoles of the general formula wherein R is a monobromo-, monofluoro-, dichloro- or monomethyl-phenyl or monomethylbenzyl group, and pharmaceutically acceptable acid addition salts thereof are prepared by reaction of a thiourea of the general formula RNHCSNH 2 with an alkyl halide of the general formula R 1 X, wherein R 1 is a methyl or ethyl group and X is a chlorine, bromine or iodine atom, reaction of the resulting S-alkylisothiourea hydrohalide of the general formula RNHC(SR 1 ) = NH.HX with hydrazine and reaction of the resulting 4-aminoguanidine hydrohalide of the general formula RNHC( = NH)NHNH 2 .HX with nitrous acid, followed optionally by salification of the product. |
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Novel 1 - substituted - 5 - aminotetrazoles of the general formula wherein R is a monobromo-, monofluoro-, dichloro- or monomethyl-phenyl or monomethylbenzyl group, and pharmaceutically acceptable acid addition salts thereof are prepared by reaction of a thiourea of the general formula RNHCSNH 2 with an alkyl halide of the general formula R 1 X, wherein R 1 is a methyl or ethyl group and X is a chlorine, bromine or iodine atom, reaction of the resulting S-alkylisothiourea hydrohalide of the general formula RNHC(SR 1 ) = NH.HX with hydrazine and reaction of the resulting 4-aminoguanidine hydrohalide of the general formula RNHC( = NH)NHNH 2 .HX with nitrous acid, followed optionally by salification of the product.</abstract><oa>free_for_read</oa></addata></record> |
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| title | 1 - (SUBSTITUTED) - 5 - AMINOTETRAZOLES AND TREATMENT OF INFLAMMATION OF THE ANIMAL ORGANISM THEREWITH |
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