N-aryloxyalkyl n-aralkoxyamines and related compounds

The invention comprises compounds of the formula (wherein X and X1 are hydrogen, halogen or C1- 6 alkyl; n is 1 or 3; m is 2, 3 or 4; and Z is hydrogen, -CO.R or -CO.OR in which R is alkyl or aryl) and, when Z is hydrogen, acid-addition salts thereof; and their preparation by reacting a compound of the formula (prepared by condensing an appropriate aralkyl halide with an alkoxycarbonyl-hydroxylamine, i.e. an N-hydroxy-alkylcarbamate) with an aryloxyalkyl halide to give a product wherein Z is -CO.O alkyl and, if desired, hydrolysing this with alkali to give a product wherein Z is hydrogen and, if desired, acylating this with an acyl halide or reacting it with an alkyl or aryl chloroformate to give a product wherein Z is -CO.R or -CO.OR respectively. Examples are given. The N-aryloxyalkyl N-aralkoxyamines of the invention, which are stated to lower the blood-cholesterol of warm-blooded animals, may be made up into pharmaceutical compositions with suitable carriers. Tablets, capsules and solutions are referred to.