5 amino-1-phenyltetrazole muscle relaxant preparations

5 - Amino - 1 - phenyltetrazole is prepared by refluxing phenylthiourea with CH3I in ethanol to yield 1-phenyl-S-methylisothiourea hydriodide. The latter is reacted with hydrazine to give 1 - phenyl - 3 - aminoguanidine hydriodide, which is converted into 5-amino-1-phenyl-tetrazole by treatment (a) with AgNO3/conc. HNO3 and then conc. HCl to precipitate silver halides and (b) with NaNO2 and Na2CO3 in cooled solution. Salts of the compound may be prepared by reaction with acid, e.g. H2SO4, HBr, H3PO4, CH3.COOH, citric, lactic, tartaric, sulphamic, succinic, maleic, fumaric, or ethanedisulphonic acid.ALSO:Pharmaceutical preparations having muscle-relaxants and anti-inflammatory activity comprise 5-amino-1-phenyl-tetrazole, or an acid-addition salt thereof, and a carrier. The preparations, which may be administered to animals or humans, may be in the form of tablets, powders, capsules, troches, lozenges, solutions, or suspensions. The preparations may be administered orally or parenterally or directly to the site of the inflammatory condition. The carrier, which may be solid or liquid may also include a time-delay material.