METHODS FOR PREPARING AND ADMINISTERING CRYOPRESERVED PLATELETS AND PLATELET DERIVATIVES LOADED WITH ANTI-CANCER DRUGS

In some embodiments, provided herein is a composition comprising cryopreserved anti-cancer drug-loaded platelet composition, and a process for preparing the same, in illustrative embodiments, cryopreserved anti-cancer drug-loaded platelet composition can be stored at a temperature in a range of −10° C. to −30° C. for at least 1 month. The anti-cancer drug-loaded platelets in the composition can be platelet derivatives. In some embodiments provided herein are methods of preparing anti-cancer drug loaded platelet derivatives, or cryopreserved anti-cancer drug-loaded platelets, comprising: incubating platelets with an anti-cancer drug, and with a loading buffer comprising a monosaccharide and/or a disaccharide, to form anti-cancer drug-loaded platelets, and lyophilizing or freezing the anti-cancer drug-loaded platelets, to form anti-cancer drug loaded platelet derivatives, or cryopreserved anti-cancer drug-loaded platelets, respectively. In some embodiments, provided herein are methods of administering anti-cancer drug loaded platelet derivatives and cryopreserved platelets.