EXPRESSION CASSETTE COMBINATIONS AND USES THEREOF

The present application relates to expression cassette combinations and uses thereof. The expression cassette combination comprises a first expression cassette and a second expression cassette, wherein the first expression cassette can express an N-terminal truncated version of an ABCA4 protein, the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shi, Tianyong, Chen, Shaohong, Zhong, Xiancheng
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present application relates to expression cassette combinations and uses thereof. The expression cassette combination comprises a first expression cassette and a second expression cassette, wherein the first expression cassette can express an N-terminal truncated version of an ABCA4 protein, the second expression cassette can express a C-terminal truncated version of an ABCA4 protein, and the N-terminal truncated version of the ABCA4 protein and the C-terminal truncated version of the ABCA4 protein can possess the biological functions of a complete ABCA4 protein without forming the complete ABCA4 protein therefrom.