COMPOSITIONS AND SYSTEMS FOR REGULATION OF FUNCTION/ABUNDANCE AND DELIVERY OF POLYPEPTIDE PAYLOADS

Provided herein are engineered, regulatable polypeptides comprising a payload and a modulation hub with at least two drug responsive domains (DRD), wherein the modulation hub is operably linked to the payload and wherein the at least two DRDs are responsive to a ligand. Also provided are engineered...

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Bibliographische Detailangaben
Hauptverfasser:	ter Meulen, Jan, Sun, Dexue, Sethi, Dhruv, Schebesta, Michael, Ols, Michelle, Smith, Sean, Li, Dan Jun
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are engineered, regulatable polypeptides comprising a payload and a modulation hub with at least two drug responsive domains (DRD), wherein the modulation hub is operably linked to the payload and wherein the at least two DRDs are responsive to a ligand. Also provided are engineered monomers comprising an oligomerization domain and a payload, a DRD or both a payload and DRD, wherein the monomers are configured to assemble into oligomers by way of the oligomerization domain and the oligomers comprise at least one payload operably linked to a modulation hub. The abundance, availability and/or biological activity of the payload is regulated by interaction of the one or more DRDs and an effective amount of ligand.