Therapeutic Use of Bispecific Anti-Abeta/TfR Antibodies

Herein is reported a bispecific antibody specifically binding to human Abeta protein and human transferrin receptor (bispecific anti-Abeta/TfR antibody) as well as the use of such bispecific antibodies as a medicament in the treatment of Alzheimer's Disease, including where the bispecific antib...

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Bibliographische Detailangaben
Hauptverfasser:	KLEIN, Gregory, AGNEW, David Andrew, HOFMANN, Carsten Harald, MARCHESI, Maddalena, CRONEY, Ruth Emma, KULIC, Luka, JORDAN, Paul Philipp Max, SVOBODA, Hanno, ALCARAZ, Fabien Eric, ABRANTES, João André, VOGT, Annamarie
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Herein is reported a bispecific antibody specifically binding to human Abeta protein and human transferrin receptor (bispecific anti-Abeta/TfR antibody) as well as the use of such bispecific antibodies as a medicament in the treatment of Alzheimer's Disease, including where the bispecific antibody is administered intravenously at a dose of 0.2 mg/kg to 7.2 mg/kg once every four weeks.