ENGINEERED DUAL BINDING ANTIBODIES AND USES THEREOF

ENGINEERED DUAL BINDING ANTIBODIES AND USES THEREOF

Described herein are engineered dual binding antibodies that bind to IL-13 and TSLP and uses thereof. Uses include treating allergic and respiratory conditions. Described herein are also libraries comprising the engineered dual binding antibodies, and methods of producing the engineered dual binding...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: OFRAN, Yanay, MALCHENKO, Nikol, NIMROD, Guy, GROSSMAN, Noam, SHLAMKOVICH, Tomer, FISCHMAN, Sharon, DEMISHTEIN, ALIK, DANIELPUR, Liron, SHNYDER, Alexey, IFRACH, Morya, CHEN, Ayelet, BLUVSHTEIN YERMOLAEV, Olga, ZHENIN, Michael, STRAJBL, Marek, BARAK FUCHS, Reut, SASSON, Yehezkel, BERNSTEIN, Shmuel, MEIR, Itzhak, LEVIN, Itay, GATTEGNO, Hadar
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Described herein are engineered dual binding antibodies that bind to IL-13 and TSLP and uses thereof. Uses include treating allergic and respiratory conditions. Described herein are also libraries comprising the engineered dual binding antibodies, and methods of producing the engineered dual binding antibodies and functional and biochemical characterization of the antibodies.