PROCESS FOR MANUFACTURING ORALLY DISINTEGRATING TABLET COMPRISING CYTOKINE

The present application provides a process for manufacturing an orally disintegrating tablet (ODT) comprising a cytokine as an active pharmaceutical ingredient comprising: acidifying an excipient, conducting a first granulation step of the acidified excipient to obtain acidic powders, and conducting...

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Bibliographische Detailangaben
Hauptverfasser: TSAI, Chun-Jung, TSAI, Chun-Hsien, LEE, Ting-Chuan, YU, Tsung-Fu, TIEN, Yi-Yu
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present application provides a process for manufacturing an orally disintegrating tablet (ODT) comprising a cytokine as an active pharmaceutical ingredient comprising: acidifying an excipient, conducting a first granulation step of the acidified excipient to obtain acidic powders, and conducting a second granulation step by mixing the acidic powders and the cytokine to obtain granules containing the cytokine. The present application also provides an ODT manufactured by the process.