TARGETED INTERFERON ALPHA FUSION PROTEINS AND METHODS OF USE

The invention provides fusion proteins that comprise a human IFN-α2, a first antigen-binding domain capable of binding to human PD-L1, a second antigen-binding domain capable of binding to human PD-L1 and to human IFN-α2, and methods of using the same.

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Bibliographische Detailangaben
Hauptverfasser:	RAPP, Moritz, BRINKMANN, Ulrich, BATES, Jack Anthony, DUERR, Harald, BERTOLDO, Davide, SYDOW-ANDERSEN, Jasmin, UMAÑA, Pablo, WOLF, Monika
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides fusion proteins that comprise a human IFN-α2, a first antigen-binding domain capable of binding to human PD-L1, a second antigen-binding domain capable of binding to human PD-L1 and to human IFN-α2, and methods of using the same.