CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF

The present application relates to a chimeric antigen receptor (CAR), comprising a GPC3 binding domain, a transmembrane domain, a costimulatory domain and an intracellular signaling domain, the GPC3 binding domain comprises an antibody or a fragment thereof which specifically binding to GPC3, the an...

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Bibliographische Detailangaben
Hauptverfasser:	YANG, Qi, HE, Xiaowen, XU, Yanhong, CHEN, Siye, YANG, Yue, LI, Huijiao, XU, Zhifeng, YANG, Huanfeng, GUO, Hao, LING, Youguo, LI, Xiaopei
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present application relates to a chimeric antigen receptor (CAR), comprising a GPC3 binding domain, a transmembrane domain, a costimulatory domain and an intracellular signaling domain, the GPC3 binding domain comprises an antibody or a fragment thereof which specifically binding to GPC3, the antibody comprises a light chain complementary determining region 1 (LCDR1), a light chain complementary determining region 2 (LCDR2) and a light chain complementary determining region 3 (LCDR3), the amino acid sequence of the LCDR1 is as set forth in SEQ ID NO: 16, the amino acid sequence of the LCDR2 is as set forth in SEQ ID NO: 17 and the amino acid sequence of the LCDR3 is as set forth in SEQ ID NO: 18. The present application also relates to an isolated nucleic acid encoding the CAR, a vector comprising the nucleic acid, an immune effector cell comprising the nucleic acid or the vector and a preparation method thereof as well as a use of the CAR.