COMBINED HER2 AND MESO DUAL-TARGET CAR-T VECTOR, CONSTRUCTION METHOD THEREFOR AND APPLICATION THEREOF IN CANCER

A combined HER2 and MESO dual-target CAR-T vector, a construction method therefor and an application thereof in cancer are provided; specifically, a bispecific chimeric antigen receptor (CAR) containing HER2 scFv and MESO scFv, a 4-1BB co-stimulatory domain, and a CD3 activation domain is provided....

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Bibliographische Detailangaben
Hauptverfasser:	XIONG, Feifei, ZHOU, Xu, ZHENG, Mei, LIU, Xueying, DING, Yahong, JIANG, Fengting, LUO, Jian
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A combined HER2 and MESO dual-target CAR-T vector, a construction method therefor and an application thereof in cancer are provided; specifically, a bispecific chimeric antigen receptor (CAR) containing HER2 scFv and MESO scFv, a 4-1BB co-stimulatory domain, and a CD3 activation domain is provided. The bispecific CAR-T cell has a significant killing effect on HER2-positive target cells and MESO-positive target cells and can improve on the tumor-killing effect of T cells; the cytokines produced have a super-additive effect, and compared with a single-target CAR-T, can better clear tumor cells, alleviate antigen escape caused by tumor heterogeneity, and further strengthen the ability of CAR-T cells to kill tumors.