CD47/PD-L1-TARGETING PROTEIN COMPLEX AND METHODS OF USE THEREOF

CD47/PD-L1-TARGETING PROTEIN COMPLEX AND METHODS OF USE THEREOF

This disclosure relates to protein complexes targeting CD47, PD-L1, and/or TGFβ, and methods of use thereof. In one aspect, the protein complexes include one or more CD47-binding domains, each including all or a portion of the SIRPα extracellular region; one or more PD-L1-binding domains, each inclu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tseng, Chi-Ling, Wang, Jiin-Tarng, Juo, Zong Sean
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This disclosure relates to protein complexes targeting CD47, PD-L1, and/or TGFβ, and methods of use thereof. In one aspect, the protein complexes include one or more CD47-binding domains, each including all or a portion of the SIRPα extracellular region; one or more PD-L1-binding domains, each including all or a portion of the PD-1 extracellular region; and optionally one or more TGFβ-binding domains, each including all or a portion of the TGFβR2 extracellular region.