END-TO-END ISOLATION OVER PCIE

Examples systems are provided for isolating transactions originating from different types of applications, including systems for providing such isolation on an inbound side and systems for providing such isolation on an outbound side, as well as end-to-end isolation systems. Such systems may be implemented in a peripheral component interconnect express (PCIe) environment. On an outbound side, a first interconnect receives transactions having different attributes indicating different application origins, respectively, and selects different pathways for the transactions based on their respective attributes. On an inbound side, a second interconnect selects different pathways for the transactions based on their respective attributes. Thus, transactions originating from safety and non-safety applications may be kept isolated as they are routed, and a non-safety transaction may be restricted from accessing certain portions of memory.