A PHARMACEUTICAL FORMULATION OF IMMUNE CHECK POINT INHIBITORS

The present invention relates to pharmaceutical formulations of antibodies and antigen-binding fragments against human programmed death receptor-1 (PD-1)/programmed death receptor Ligand 1 (PD-L1), and method for preparing the same. The disclosed formulations are free of chelators and stabilizes ant...

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Bibliographische Detailangaben
Hauptverfasser:	NANATH, Maya, INGALE, Mahesh, SURESH, Abirami, PRIYA, R. L. Shri Ranga, JACOB, Reinhard, SARKAR, Puja, LABALA, Suman, K GOUD, Saisharan, JAYARAMAN, Murali, NANKAR, Sunil Ashok, AGGARWAL, Lovisha
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical formulations of antibodies and antigen-binding fragments against human programmed death receptor-1 (PD-1)/programmed death receptor Ligand 1 (PD-L1), and method for preparing the same. The disclosed formulations are free of chelators and stabilizes anti-PD1/anti-PD L1 antibody from lower to higher concentrations rendering it suitable for different modes of administration (subcutaneous/intravenous).