METHOD OF PRODUCING AN IMMUNOGENIC COMPOSITION

The present invention in particular relates to a method of producing an immunogenic composition exhibiting reduced virucidal activity, as well as to the immunogenic composition and uses thereof, wherein the method in particular comprises the steps of: (a) providing a mixture with a first liquid and...

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Bibliographische Detailangaben
Hauptverfasser: COONS, Matthew, ORVEILLON, Francois-Xavier, WILMES, Leigh, GASSEL, Michael Johannes, TOEPFER, Katharina Hedwig, BAUTISTA, Elida, SCHLESINGER, Kathy, BROWN, Amanda
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention in particular relates to a method of producing an immunogenic composition exhibiting reduced virucidal activity, as well as to the immunogenic composition and uses thereof, wherein the method in particular comprises the steps of: (a) providing a mixture with a first liquid and a recombinant protein, (b) concentrating the recombinant protein in the mixture by removing a portion of the first liquid from the mixture, and (c) processing the solution resulting from step (b) by continuous diafiltration.