Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs

Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs

Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dixit, Surjit Bhimarao, Spreter von Kreudenstein, Thomas, Ng, Gordon Yiu Kon, Weisser, Nina E
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer constructs are based on a heterodimeric Fc scaffold or on a segmented albumin scaffold. Also disclosed herein are multi-specific heteromultimer constructs that bind to HER2 and HER3.