SYSTEM AND METHOD FOR DRUG SELECTION

A method of treating a subject for a disease comprises obtaining a first data set of cell transcriptomic data, obtaining a second set of cell transcriptomic data, obtaining a set of effectiveness data related to a plurality of candidate medications or treatments related to the samples, calculating a...

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Bibliographische Detailangaben
Hauptverfasser:	Yi, Song Stephen, Bui, Willard, Osorio Hurtado, Daniel Camilo, Sahni, Nidhi
Format:	Patent
Sprache:	eng
Schlagworte:	HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS PHYSICS
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Beschreibung
Zusammenfassung:	A method of treating a subject for a disease comprises obtaining a first data set of cell transcriptomic data, obtaining a second set of cell transcriptomic data, obtaining a set of effectiveness data related to a plurality of candidate medications or treatments related to the samples, calculating a lower-dimensional model from the first set of cell transcriptomic data, assigning the second set of cell transcriptomic data to at least one group of the plurality of groups, calculating a synergistic effectiveness of combinations in a set of candidate medication or treatment combinations related to each group of the plurality of groups of cell lines, selecting a treatment combination from the set of candidate medication or treatment combinations whose synergistic effectiveness is above a threshold for the at least one group, and treating the subject with the selected treatment combination.