PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and a...
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| creator | DODD, David ESTANDIAN, Daniel Masao YANG, Joshua Young Cynming WASSIE, Asmamaw HUA, Boyang SU, Elaine Jean PRICE, Andrew John DELGADO, Gerardo Fabian |
| description | Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps. |
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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES |
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