PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES

PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES

Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DODD, David, ESTANDIAN, Daniel Masao, YANG, Joshua Young Cynming, WASSIE, Asmamaw, HUA, Boyang, SU, Elaine Jean, PRICE, Andrew John, DELGADO, Gerardo Fabian
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.