SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

The present invention provides, in part, compounds and methods for treating diseases mediated by PHD1 activity (e.g., ischemia reperfusion injury (including but not limited to stroke, myocardial infarction, and acute kidney injury) inflammatory bowel disease, cancer (including colorectal cancer) and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BLAISDELL, Thomas P, FLEMING, Paul E
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides, in part, compounds and methods for treating diseases mediated by PHD1 activity (e.g., ischemia reperfusion injury (including but not limited to stroke, myocardial infarction, and acute kidney injury) inflammatory bowel disease, cancer (including colorectal cancer) and liver disease) comprising administering to a subject to a subject a compound of Formula (I), and sub-formulas thereof:or a pharmaceutically acceptable salt thereof.