DEVICES AND METHODS FOR SAMPLE DISSOCIATION AND MANIPULATION IN A MICROFLUIDIC SYSTEM

A microfluidic device and a method for dissociating and manipulating cells or particles in a microfluidic channel are disclosed. The microfluidic device includes an inlet, an outlet, and a microfluidic channel arranged on a substrate between the inlet and the outlet. The microfluidic device includes...

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Bibliographische Detailangaben
Hauptverfasser:	Sethi, Rakesh, Piskun, Vadim, Giri, Manish
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL TRANSPORTING
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Beschreibung
Zusammenfassung:	A microfluidic device and a method for dissociating and manipulating cells or particles in a microfluidic channel are disclosed. The microfluidic device includes an inlet, an outlet, and a microfluidic channel arranged on a substrate between the inlet and the outlet. The microfluidic device includes a first set of piezoelectric actuators arranged adjacent to the inlet channel and configured to dissociate particles of a fluidic sample in the microfluidic channel. The microfluidic device includes a second set of piezoelectric actuators arranged between the inlet channel and the outlet channel and configured to manipulate the particles of the fluidic sample as the particles move through the microfluidic channel. The microfluidic device includes a third set of piezoelectric actuators arranged above the outlet channel, adjacent to the outlet, and configured to eject a portion of the fluidic sample out of the microfluidic channel via the outlet.