MULTISPECIFIC BINDING AGENTS AGAINST CD40 AND CD137 IN COMBINATION THERAPY FOR CANCER

The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer.

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Bibliographische Detailangaben
Hauptverfasser:	KUZMANOV, Ivan, SPIRES, Vanessa, LABRIJN, Aran Frank, BLUM, Jordan, FELLERMEIER-KOPF, Sina, SAHIN, Ugur, PAULMANN, Claudia, HIGGS, Brandon, FERESHTEH, Mark, NIEWOOD, Michelle, BECKMANN, Karsten, MUIK, Alexander, HIBBERT, Richard, ADAMS, III, Homer, GARRIDO CASTRO, Patricia, BAJAJ, Gaurav, DE KREUK, Bart-Jan, GUELEN, Lars, NEIJSSEN, Jost, FU, Yali, GIESEKE, Friederike, SCHUURMAN, Janine, BREIJ, Esther Cornelia Wilhelmina
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer.