APELIN POLYPEPTIDES

The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as h...

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Bibliographische Detailangaben
Hauptverfasser:	SIEGMUND, Aaron C, FROHN, Michael J, MIRANDA, Leslie P, LANMAN, Brian Alan, YANG, Bryant, PICKRELL, Alexander J, PENNINGTON, Lewis D, SWAMINATH, Gayathri, REED, Anthony B, ALLEN, John Gordon, HOLDER, Jerry Ryan
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.