ANTI-BACTERIAL EFFECT OF HALOGENATED FLUORESCEINS AGAINST COLISTIN-RESISTANT GRAM-NEGATIVE BACTERIA

of treating Gram-negative bacteria that also exhibit resistance to the anti-bacterial compound colistin (MIC≥50 mg/mL) except for Burkholderia, Proteus, and Serratia that comprises contacting the bacteria with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of Formula I,...

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Bibliographische Detailangaben
Hauptverfasser:	Horowitz, Bruce, KUROSU, Michio, Rodrigues, Dominic, Lacey, John, Wachter, Eric A, Pershing, Edward V
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ELECTROTHERAPY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MAGNETOTHERAPY MEDICAL OR VETERINARY SCIENCE PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF RADIATION THERAPY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING ULTRASOUND THERAPY
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Beschreibung
Zusammenfassung:	of treating Gram-negative bacteria that also exhibit resistance to the anti-bacterial compound colistin (MIC≥50 mg/mL) except for Burkholderia, Proteus, and Serratia that comprises contacting the bacteria with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of Formula I, below, dissolved or dispersed therein at a concentration of about 0.01 to about 15 mg/mL and irradiating those contacted bacteria with light of the wavelength about 500 nm to about 600 nm for a time period of about 1 to about 10 minutes to provide a light dose of about 16 to about 160 J/cm2, treat and kill the irradiated bacteriawherein X, R1, R2 and M+ are defined within.