ANTI-HER-2 ANTIBODY-CHEMOKINE FUSION PROTEIN, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Provided are an anti-Her-2 antibody-chemokine fusion protein, a preparation method therefor and an application thereof. Specifically, provided is a fusion protein, the fusion protein comprising an anti-Her-2 antibody or an active fragment thereof and a chemokine. The fusion protein of the present in...

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Bibliographische Detailangaben
Hauptverfasser:	Cai, Zeling, Chen, Yi
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are an anti-Her-2 antibody-chemokine fusion protein, a preparation method therefor and an application thereof. Specifically, provided is a fusion protein, the fusion protein comprising an anti-Her-2 antibody or an active fragment thereof and a chemokine. The fusion protein of the present invention enhances the lethality of eosinophils in a tumor microenvironment by means of CCL11-mediated chemotaxis while being able to recognize tumors abnormally expressing Her-2 and inhibiting the growth thereof, further enhancing the lethality thereof toward Her-2+ tumors.