LINEAR PEPTIDES INHIBITING CK2-MEDIATED PHOSPHORYLATION AND COMPOSITIONS COMPRISING SAME

LINEAR PEPTIDES INHIBITING CK2-MEDIATED PHOSPHORYLATION AND COMPOSITIONS COMPRISING SAME

Linear peptides that inhibit the phosphorylation mediated by the enzyme Casein Kinase 2 (CK2), which have an amino acid sequence selected from the group consisting of the sequences identified as SEQ ID NO: 45, SEQ ID NO: 49, SEQ ID NO: 50, and SEQ ID NO: 57-SEQ ID NO: 62, as well as polypeptides com...

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Hauptverfasser: PERERA NEGRÍN, Yasser, BESADA PÉREZ, Vladimir Armando, GARAY PÉREZ, Hilda Elisa, REYES ACOSTA, Osvaldo, PEREA RODRÍGUEZ, Silvio Ernesto, GONZÁLEZ BLANCO, Sonia, MASFORROL GONZÁLEZ, Yordanka, GONZÁLEZ LÓPEZ, Luis Javier, GUILLÉN NIETO, Gerardo Enrique, CABALLERO MENÉNDEZ, Evelin
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Linear peptides that inhibit the phosphorylation mediated by the enzyme Casein Kinase 2 (CK2), which have an amino acid sequence selected from the group consisting of the sequences identified as SEQ ID NO: 45, SEQ ID NO: 49, SEQ ID NO: 50, and SEQ ID NO: 57-SEQ ID NO: 62, as well as polypeptides comprising said peptides and an intracellular penetrating peptide. A pharmaceutical composition comprising at least one of these linear peptides or polypeptides and a pharmaceutically acceptable carrier. The invention also discloses the use of said peptides or polypeptides for the manufacture of a drug, and a method of treating solid or liquid tumors where said drug is administered.