PROCESSES FOR PURIFICATION OF BICTEGRAVIR INTERMEDIATES

PROCESSES FOR PURIFICATION OF BICTEGRAVIR INTERMEDIATES

The present invention generally relates to a process for purification of (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5] pyrazino [2,1-b] [1,3] oxazepine-10-carboxylic acid of Formula I and (2R,5S,13aR)-8-methoxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl)]...

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Bibliographische Detailangaben
Hauptverfasser: THAIMATTAM, Ram, PEDDINTI, Giri Babu, VASIREDDI, Uma Maheswar Rao, BALUSU, Raja Babu, DAMMALAPATI, Venkata Lakshmi Narasimha Rao, PODILE, Nagarjuna
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention generally relates to a process for purification of (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5] pyrazino [2,1-b] [1,3] oxazepine-10-carboxylic acid of Formula I and (2R,5S,13aR)-8-methoxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl)]-2,3,4,5,7,9,13,13a-octahydro-2,5-methano pyrido-[1′,2′:4,5] pyrazino[2,1-b] [1,3]-oxazepine-10-carboxamide of Formula II, an intermediates for the preparation of bictegravir.