METHODS TO CHARACTERIZE FUNCTIONAL AND DYSFUNCTIONAL ACUTE INFLAMMATORY RESPONSES TO PATHOLOGIC PROCESSES

Systems and methods for generating a trajectory model characterizing a disease state and using the trajectory model in determining a recommended treatment. In one aspect, a method includes obtaining patient data, in which the patient data includes clinical laboratory results of a patient with a disease state; processing the patient data such that the clinical laboratory results are normalized by patient-specific or cohort-specific baseline levels of the clinical laboratory results; and applying a trajectory model to the processed patient data to identify a likelihood of an adverse outcome of the patient, in which the trajectory model characterizes the disease state by a recovery trajectory in a phase-plane of one or more variables.