PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF

PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders...

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Hauptverfasser: WALTERS, W. Patrick, PIERCE, Levi CharlesThomas, GIORDANETTO, Fabrizio, LANDAGARAY, Elodie, RAYNOR, Kevin David, BURNIE, Andrew J, VEMULA, Naresh, ATIENZA, Bren-Jordan, OUTIN, Johanne, CHITALE, Sampada, LESCARBEAU, André, LEPITRE, Thomas, DENINNO, Michael Paul, KRUEGER, Elaine B, KURUKULASURIYA, Ravi, MAERTENS, Gaetan, GUNAYDIN, Hakan, BERTRAND-LAPERLE, Megan, DIPIETRO, Lucian V, MCLEAN, Thomas H, FRIDRICH, Cary Griffin, ZHANG, Hanmo, PAN, Yue, MOHAMED, Tarek, THORAT, Rakesh, GELOZIA, Shorena, WANG, Qi, SHORTSLEEVES, Kelley C, PECHERSKY, Yakov, TANG, Yong, STURINO, Claudio, LARIVEE, Alexandre, MADER, Mary M, TAYLOR, Alexander M, BOEZIO, Alessandro, BOUSQUET, Yves, LEE, Jessica, JOBIN-DES LAURIERS, Antoine, PAL, Mohan, GIGUERE, Jean-Benoit, TANVEER, Kashif, CHEN, Fei
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-α signaling with the compounds and compositions of the disclosure.