PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to pyrazolyl-pyrimidine derivatives, to a process for their preparation, to pharmaceutical compositions comprising them, and to their use as therapeutic agents. The compounds are kinase inhibitors, in particular are inhibitors of Spleen Tyrosine Kinase (SYK) and can be...

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Bibliographische Detailangaben
Hauptverfasser:	CERVI, Giovanni, BUFFA, Laura, BINDI, Simona, MENICHINCHERI, Maria, MODUGNO, Michele, D'ALESSIO, Roberto
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to pyrazolyl-pyrimidine derivatives, to a process for their preparation, to pharmaceutical compositions comprising them, and to their use as therapeutic agents. The compounds are kinase inhibitors, in particular are inhibitors of Spleen Tyrosine Kinase (SYK) and can be used in treatment of cancer, cell proliferative disorders, viral infections, immune disorders, neurodegenerative disorders and cardiovascular diseases.