NUCLEIC ACID NANOPARTICLES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

The present disclosure relates to a nucleic acid nanoparticle comprising a single stranded nucleic acid scaffold encoding one or more RNA molecules of interest and a plurality of single stranded nucleic acid oligomers, where each oligomer is complementary to at least a portion of the single stranded...

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Bibliographische Detailangaben
Hauptverfasser:	OH, Chang Yong, HENDERSON, Eric
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to a nucleic acid nanoparticle comprising a single stranded nucleic acid scaffold encoding one or more RNA molecules of interest and a plurality of single stranded nucleic acid oligomers, where each oligomer is complementary to at least a portion of the single stranded nucleic acid scaffold. Also disclosed are pharmaceutical compositions and methods of use thereof.