CHIMERIC PROTEINS FOR TARGETED DELIVERY OF GROWTH FACTORS TO THE GLOMERULUS

CHIMERIC PROTEINS FOR TARGETED DELIVERY OF GROWTH FACTORS TO THE GLOMERULUS

Aspects of the present disclosure relate generally to chimeric proteins and pharmaceutical compositions comprising such chimeric proteins, and methods for using such chimeric proteins for treating kidney diseases. Aspects of the disclosure relate to chimeric protein comprising a targeting domain com...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Olsen, Walter, Chawla, Lakhmir S, Kuchenbecker, Kristopher M, Pfaff, Samuel J, Zhang, Yan
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Aspects of the present disclosure relate generally to chimeric proteins and pharmaceutical compositions comprising such chimeric proteins, and methods for using such chimeric proteins for treating kidney diseases. Aspects of the disclosure relate to chimeric protein comprising a targeting domain comprising a scFv having a binding specificity to a cell surface protein of a kidney tissue, and an activator domain comprising a growth factor.