ANTIGEN-BINDING MOLECULE COMPRISING ALTERED ANTIBODY VARIABLE REGION BINDING CD3 AND CD137

Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigens more efficiently are also provided.

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Bibliographische Detailangaben
Hauptverfasser:	Ho, Shu Wen Samantha, Miyazaki, Taro, Sakurai, Mika, Igawa, Tomoyuki, Shimizu, Shun, Hironiwa, Naoka
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMBINATORIAL CHEMISTRY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigens more efficiently are also provided.