METHOD TO ASSESS NODAL DISEASE USING IRON OXIDE NANOPARTICLES IN MAGNETIC RESONANCE IMAGING

This invention relates to a method to assess nodal disease by magnetic resonance imaging with a contrast agent. The contrast agent comprises biofunctional magnetic nanoparticles coated with polymers outside the iron core and conjugated with antibodies specific to the tumor type to be assessed. Image...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, Marie, JAYALAKSHMI, Yalia, LAU, Wing Fai, PROULX, Robert, YANG, Natalie
Format:	Patent
Sprache:	eng
Schlagworte:	DIAGNOSIS HUMAN NECESSITIES HYGIENE IDENTIFICATION MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SURGERY TRANSPORTING
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Beschreibung
Zusammenfassung:	This invention relates to a method to assess nodal disease by magnetic resonance imaging with a contrast agent. The contrast agent comprises biofunctional magnetic nanoparticles coated with polymers outside the iron core and conjugated with antibodies specific to the tumor type to be assessed. Images produced from this magnetic resonance imaging with a contrast agent show heterogenous hypo intensity or heterogenous architecture in regions where binding by the antibodies is present.