PROTEOMIC ANALYSIS WITH NUCLEIC ACID IDENTIFIERS

The disclosure provides methods and compositions useful for labeling of target molecules with origin-specific nucleic acid identifiers (for example, barcodes), which can be used subsequently to identify, quantify, or otherwise characterize a feature or activity of target molecules originating from a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kirk, Timothy V, Saudemont, Baptiste, Nicol, Robert, Griffiths, Andrew David
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The disclosure provides methods and compositions useful for labeling of target molecules with origin-specific nucleic acid identifiers (for example, barcodes), which can be used subsequently to identify, quantify, or otherwise characterize a feature or activity of target molecules originating from a particular discreet volume. Such target molecules can include polypeptides expressed by cells, in which nucleic acid molecules encoding the polypeptides are labeled with the same, or matched, origin-specific nucleic acid identifiers.