TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA

Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- an...

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Hauptverfasser:	DREW, Samuel Lawrie, EPPLIN, Matthew, MOON, Hyunyoung, LINDSEY, Erick Allen, LAWSON, Kenneth Victor, POWERS, Jay Patrick, BEATTY, Joel Worley, GAL, Balint, JACOB, Steven Donald, MAILYAN, Artur Karenovich, FOURNIER, Jeremy Thomas Andre, MANDAL, Debashis, LELETI, Manmohan Reddy, WANG, Zhang, KALISIAK, Jaroslaw, MATA, Guillaume, ROSEN, Brandon Reid, JEFFREY, Jenna Leigh, HAELSIG, Karl T, HARDMAN, Clayton, TRAN, Anh Thu, YU, Kai, SU, Yongli, GUNEY, Tezcan, YAN, Xuelei
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.